In some situations, it may be required to uninstall GlobalProtect app from your Mac, for example to replace existing installation of an older version that fails to update itself with a managed installation via Company Portal. If you attempt to uninstall GlobalProtect in Finder by selecting Move to Trash, you will see an error message that says "The item "GlobalProtect" can't be moved to the Trash because it is open." You will need to follow these steps to shut down GlobalProtect first and prevent it from restarting itself before removing it:
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Open the Finder and go to the Applications folder then control-click GlobalProtect app and select Show Package Contents.
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Open Contents folder.
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Open MacOS folder.
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Control-click GlobalProtect app and select Move to Trash.
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Enter your password when prompted.
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Click on the Go menu and select Utilities.
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Locate the Activity Monitor icon on the screen and double-click on it to open it.
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Under Activity Monitor, locate GlobalProtect process and double-click on it to see details.
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Click Quit button located on the bottom of the GlobalProtect dialogue box.
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Another dialog box will pop up, asking if you are sure you would like to quit the this process. Click the Force Quit button.
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You can now go back to Finder and go to the Applications folder then control-click GlobalProtect app and select Move to Trash.
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Click Continue when prompted with a message "The application GlobalProtect is hosting system extensions..."
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Enter your password when prompted.
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Empty Trash.